Background:
Depression and osteoporosis are severe public health problems. There are conflicting findings regarding the influence of depression on bone metabolism. Depression has been linked to an increased risk of osteoporosis, but the underlying mechanisms remain unclear. Depression has been implicated as a possible risk factor for low bone mineral density (BMD). However, there is still no solid evidence that could connect these two different illnesses. Many studies in this area are observational, which means they can show associations but not prove causation.
Aim:
The aim of the presented study was to compare bone turnover markers between osteoporosis patients associated with depression and healthy controls.
Methods:
We determined a concentration of serum cortisol, creatinine, TSH and 1,25(OH)2D3 in 60 osteoporotic patients, aged 46.9 ± 17 years, associated with depression, as well as in 60 healthy subjects. Depressive status was determined with the Hamilton Depression Scale (HAMD).
Results:
In osteoporotic patients with depression, we observed significantly lower bone mineral density concentrations (p < 0.05) and higher concentration of cortisol (result on the border of significance; p = 0.08). The level of TSH and 1,25(OH)2D3 did not differ significantly between the examined groups. We observed a negative correlation of the eGFR as compare with creatinine score in all osteoporotic patients with depression. We found that patients with depression had significantly higher levels of bone resorption markers (cortisol) and lower levels of bone formation markers (vitamin D) compared to healthy controls.
Conclusion:
Our results indicate that depression is related to disturbances in bone metabolism, especially in women, suggesting its role in context of osteoporosis development. Our findings suggest that bone markers may be useful in identifying individuals at risk of depression-related osteoporosis.
Key words: Depression, Bone markers, Cortisol, Vitamin D, eGFR
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