Background: Our study aims at exploring the hypoglycemic effect, efficacy and possible mode of action of ethanol extract of Alpinia nigra (EEAN) as an antidiabetic agent in animal model. Methods: Oral glucose tolerance test (OGTT) was used to identify primary hypoglycemic effect in mice. Three tests (glucose absorption, sucrose absorption and disaccharidase activity) were carried out by gut-perfusion and six segments studies to assess carbohydrate absorption and glucose utilization. Results: In OGTT, at 400 mg/kg and 800 mg/kg dose of EEAN extract significantly improved oral glucose tolerance among normal mice at 60 min and 90 min with compared to control. both doses of extract significantly (P
Key words: Alpinia nigra, OGTT, hypoglycemic effect, blood glucose, glucose tolerance
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