Seroepidemiology of hepatitis A virus in Hyderabad, South India
Syed Rahamathulla, Mohammed Aejaz Habeeb, Sindiri Prathap Kumar, Arif Aziz Nathani, V. V. Ramachandra Rao, Satti Vishnu Priya, Chandra Madhavi, Mahammad Nanne Khaja.
Abstract
The present study was carried to determine the prevalence of Hepatitis A virus (HAV) IgM antibody among general population in Hyderabad since January 2002 to December 2011. A total of 4571 subjects were selected and divided into groups on the basis of age. The serum samples were screened for the presence of HAV IgM antibodies (anti-HAV IgM) using a commercially availa-ble enzyme linked immunosorbent assay (ELISA) kit. Of the 4571 serum samples, 4257 were negative and 314 (6.87%) were positive for the HAV IgM assay. The disease predominance was more in males (212) with 67.51% compared to females (102) with 32.48%. Anti-HAV seroprevalence was measured for the following age groups: Early (≤20 years), Middle (21-40 years) and Late (≥41 years). Average age-wise IgM anti-HAV positivity from 2002-2011 was 234 of 314 in ≤20 years, 74.52%), 73 of 314 (21-40 years, 23.24%), and 7 of 314 (≥41 years, 2.22%). The present study will provide insights to the recent epidemiologic features of HAV infection in South India.
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