Urinary tract infections (UTIs) are a global concern causing annual health and economic burdens, especially with the massive prevalence of resistant uropathogens. In recent decades, medicinal plants have gained increasing attention as a promising alternative to traditional antibiotics. In this study, the antibacterial activity of the hydroalcoholic sumac extract was tested on clinical Uropathogenic Escherichia coli (UPEC) isolates including multidrug resistance strains. In the well diffusion method, sumac was effective against all bacteria in a concentration-dependent manner with an inhibition diameter of 7–15 mm for UPEC and 17–23 mm for the reference strain. Minimum inhibitory concentration/minimum bactericidal concentration were of 3.125/3.125–6.25 mg/ml for UPEC and 0.0244/1.563 mg/ ml for the reference strain. The extract reduced the hemagglutination of bacteria with human RBCs in all positive cases. Moreover, the extract inhibited the ability of UPEC to adhere to polystyrene surfaces at percentages of 79.1%– 95.1%. However, the extract did not affect the morphology of bacteria except for one isolate where it resulted in cell elongation and formation of short filaments. Long exposure to the extract did not reduce the sensitivity of the bacteria to it. Accordingly, sumac represents a promising natural antibacterial agent for the development of based pharmaceuticals to treat and prevent UTIs caused by UPEC.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
We use cookies and other tracking technologies to work properly, to analyze our website traffic, and to understand where our visitors are coming from. More InfoGot It!
