For adult teeth with necrosis or apical periodontitis, regenerative endodontics provides a useful alternative to standard endodontic treatment. This review focuses on the pediatric endodontic considerations in the application of regenerative therapy for immature permanent teeth. A thorough literature search was conducted in the MEDLINE database using the keywords “pediatric, regenerative, therapy, endodontics, immature, permanent, and teeth” to find relevant publications published between 2017 and 2024. Additionally, Google Scholar was used to find and access pertinent scientific publications using the appropriate search terms. Various inclusion criteria were applied to select the articles for review. The selected articles were published between 2020 and 2024 and included discussions on several specific elements. Topics covered include the criteria for case selection for regenerative endodontics. Overall, the existing evidence indicates that using regenerative endodontic techniques to treat adult permanent teeth with apical periodontitis or necrosis may successfully lead to the resolution of apical translucencies and the absence of clinical signs and symptoms. With slight modifications to the clinical procedure, regenerative dentistry methods can be effectively applied to specific cases, such as those involving a small apical foramen, decreased blood supply, and a lack of growth factors. However, additional research is required to determine the optimal conditions for achieving successful treatment outcomes.
Key words: Pediatric, regenerative, therapy, endodontics, immature, permanent and teeth.
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