Amoxicillin, an antibiotic with broad-spectrum bactericidal properties and beta-lactam structure, demonstrates efficacy in treating various infections. Commonly reported adverse reactions include skin rashes and urticaria (3%), vomiting (1%), nausea (3%), diarrhea/loose stools (9%), and vaginitis (1%). According to statistics from the FDA, less than 3% of patients ceased therapy as a result of adverse reactions to their prescribed medications. "The predominant adverse effects linked to penicillin use predominantly involve hypersensitivity responses. Post-marketing surveys have revealed instances of exfoliative dermatitis, including erythema multiforme, pruritus, toxic epidermal necrolysis (TEN), serum sickness-like reactions (urticaria or skin rash accompanied by myalgia, arthritis, fever, and arthralgia), and angioedema." In order to reduce the risks associated with drug use and improve patient safety and welfare, the Pharmacovigilance Program of India (PvPI) was established. The Department of Pharmacology at Pramukh Swami Medical College in Karamsad is one of the ADR Monitoring Centers (AMCs), gathering ADRs as well as case studies and series to inform the public about rare adverse reactions of certain drugs. This case report gives details of a 72 year old Male who developed TEN following the use of the Fixed Dose Combination of Amoxicillin (500mg) + Clavulanic acid (125mg) to treat infection for the epididymo-orchitis. This case report adds and increases need for awareness of rare but serious side effects of Amoxicillin+ Clavulanic acid The report emphasizes on the active ADR monitoring of drugs which may cause serious side effects like TEN
Key words: Amoxicillin ,Clavulanic acid, Toxic epidermal necrolysis
|
