This study aimed to evaluate the clinicopathological and immunological profiles of two pesticides widely used in Egypt, Lampcon and Saturn in rats. Thirty male Sprague Dawley rats divided into three groups each of 10 were used in this study. The first group received no treatment and served as control, the second group received Lampcon at a dose of 11.2 mg/kg body weight, and the third group received Saturn at a dose of 282 mg/kg body weight. The treatments were administrated daily via food for 60 successive days. Blood samples were collected for evaluating the selected hematological, biochemical and immunological parameters. The results of hematological variables implicated no significant effect on red blood cell parameters, but there was a significant leukopenia, lymphopenia and neutrophilia in both treated groups. The blood biochemical parameters showed a significant increase in serum levels of urea and enzymatic activities of ALT, AST and ALP. The findings of immunological studies clarified that Lampcon and Saturn induced oxidative stress in leukocytes and had immunosuppressive effects. The main histopathological alterations induced by Lampcon and Saturn included lymphoid depletion in lymphoid organs. Conclusion: The results from the study have shown that exposure of rats to Lampcon and Saturn pesticides pose many hematological, biochemical, and histopathological alterations in addition to immunotoxic effects. It is thus advisable that Lampcon and Saturn should be used with caution and at the recommended levels indicated by the producing company to ensure minimal exposure to these pesticides during domestic, veterinary, agricultural or industrial use.
Key words: Lampcon, Saturn, Lambda cyhalothrin, Thiocarbamate, Immunity, Rats.