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Interaction Of Newly Developed Markers Of Insulin Resistance And Liver Fibrosis

Aslihan Mete Yıldırım.




Abstract

Introduction: Insulin resistance is one of the most common causes of liver fibrosis. Instead of the Homeostatic Model Assessment- Insulin Resistance (HOMA-IR) index, which has been used to indicate insulin resistance for many years, Triglyceride-Glucose index (TyG) has recently been used, which is thought to be more predictive. (AST) to Platelet Ratio Index (APRI) and Fibrosis-4 Index (FIB-4) are newly developed markers to indicate liver fibrosis. In this study, we aimed to examine the relationship between TyG and HOMA-IR and APRI and FIB-4.
Material and Methods: 8618 patients who applied to Turgut Özal Medical Center internal medicine outpatient clinic between March 2019 and March 2024 were retrospectively examined. APRI and FIB-4 levels were compared in patients by grouping them by age and as having/not having insulin resistance according to TyG and HOMA-IR
Results: There was a statistically significant positive correlation between TyG with APRI and FIB4. (ρ= 0.041, p

Key words: Insulin resistance, Liver fibrosis, TyG, APRI, FIB-4






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