Evaluation of progranulin and inflammatory markers in the diagnosis of acute cholecystitis
Ali Ihsan Kilci, Muhammed Seyithanoglu, Erhan Kaya, Hakan Hakkoymaz, Muhammed Semih Gedik, Omer Faruk Kucuk.
Abstract
This study aimed to investigate the role of inflammatory markers and progranulin levels in diagnosing cholecystitis, assessing their potential as diagnostic biomarkers. The research involved 54 patients diagnosed with acute cholecystitis in the emergency department. Routine complete blood count and biochemistry analyses were conducted. Blood samples were obtained, centrifuged, and stored at -80°C. Progranulin levels in sera were assessed using a spectrophotometric method. Statistical analysis was carried out using SPSS v.22.0, revealing significant variances between patients and healthy controls. Acute cholecystitis patients exhibited elevated levels of inflammatory markers (white blood cells, C-reactive protein, procalcitonin) and decreased progranulin levels compared to controls. Progranulin showed a high sensitivity (86.5%) and specificity (87.5%) in diagnosing acute cholecystitis. Other markers had varying sensitivity and specificity values. Inflammatory markers, particularly progranulin, show promise in diagnosing cholecystitis. Evaluating these markers together can enhance diagnostic accuracy. Further studies are needed to validate these findings and explore progranulin's specificity to cholecystitis.
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