Wilms tumor; different histological patterns observed in local children of Pakistan
Qurat ul Ain Javaid, Nadia Naseem, Malik Adeel Anwar, Abdul Hanan Nagi.
Abstract
Objective: To describe the different histological patterns of Wilms tumor in local children of Pakistan.
Methodology: Biopsies from fresh nephrectomy specimens and paraffin embedded blocks from different hospitals of Lahore were studied.
Results: Out of 50 patients, 66% were males and 34% were females, with male: female ratio of 2:1. Mean age was 4±2.01 years. The most common clinical presentation was abdominal mass, pain and hematuria. Most common site of tumor was left kidney (68%). No bilateral tumor was found. Most common histological subtype was triphasic (56%) followed by monophasic (only blastemal;38%), biphasic (6%) and teratoid variant of wilms tumor (2%) cases. 21 cases were limited to stage I (42%), 12 progressing in stage II (24%). However stage III had only 9 (18%) cases and 8 in stage IV (16%). There was no case in stage V.
Conclusion: Wilms tumor is a common childhood malignancy in Pakistan with most common triphasic histological pattern with predominant blastema component and most frequently patients were limited to stage 1.
The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
We use cookies and other tracking technologies to work properly, to analyze our website traffic, and to understand where our visitors are coming from. More InfoGot It!
