Abstract

Objective: To describe the different histological patterns of Wilm’s tumor in local children of Pakistan.
Methodology: Biopsies from fresh nephrectomy specimens and paraffin embedded blocks from different hospitals of Lahore were studied.
Results: Out of 50 patients, 66% were males and 34% were females, with male: female ratio of 2:1. Mean age was 4±2.01 years. The most common clinical presentation was abdominal mass, pain and hematuria. Most common site of tumor was left kidney (68%). No bilateral tumor was found. Most common histological subtype was triphasic (56%) followed by monophasic (only blastemal;38%), biphasic (6%) and teratoid variant of wilm’s tumor (2%) cases. 21 cases were limited to stage I (42%), 12 progressing in stage II (24%). However stage III had only 9 (18%) cases and 8 in stage IV (16%). There was no case in stage V.
Conclusion: Wilm’s tumor is a common childhood malignancy in Pakistan with most common triphasic histological pattern with predominant blastema component and most frequently patients were limited to stage 1.

Key words: Wilm’s tumor, Histological subtype, teratoid variant.