Diabetic nephropathy (DN) is one of the major health issues associated with type 2 diabetes mellitus (T2DM). T2DM is a major risk factor for end-stage renal disease (ESRD) and chronic kidney disease. Blood urea, urine albumin, creatinine, and serum cystatin C are common markers for the diagnosis and progression of DN. Our aim was to compare the levels of serum Cystatin C and other renal parameters in patients with diabetes mellitus (DM) and DN which included 120 participants were recruited based on the inclusion and exclusion criteria; of these, 60 were suffering from type-2DM and the remaining 60 were from DN. After taking the case history, the blood and urine samples were collected and sent to the laboratory for estimation of FBS and PPBS, blood urea, serum creatinine, serum cystatin C, and urine albumin creatinine ratio. Every participant in this study had higher blood glucose levels than usual. When both groups were compared, patients with DN showed higher levels of blood urea, serum creatinine, serum cystatin C, and urine albumin creatinine ratio than those with DM. conclusion is that levels of blood urea, creatinine, serum cystatin C, and urine albumin creatinine ratio were found to be higher in patients with diabetic nephropathy as compared to DM patients. Similarly, a positive correlation was found between the urine albumin creatinine ratio and serum cystatin C levels, so it can be considered an early diagnostic marker for diabetic nephropathy.
Key words: Blood glucose, Diabetes mellitus, Diabetic nephropathy, Serum cystatin
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