A case of cycloserine induced psychosis persisting after discontinuation of the drug in the treatment of multidrug resistant tuberculosis in a 26 year old male who was been managed in the hospital for
multidrug resistant tuberculosis on daily doses of Cycloserine 500mg, Pyrazinamide 1.2g, Proteonamide 500mg, Kanamycin 750mg, Levofloxacin 750mg and Vitamin B6 200mg. At the 6th month of treatment, he developed delusional and hallucinatory experiences which subsided with the use of antipsychotics. However, antipsychotic use was not sustained leading to exacerbation of psychotic symptoms and complete
abandonment of all his anti-tubercular medications including cycloserine. Psychiatric symptoms then progressed into florid psychosis without psychiatric treatment. In conclusion the case report highlights the enduring psychiatric problems and its consequences that could be associated with the use of cycloserine in the treatment of tuberculosis and the need to integrate effective mental health liaison services for multidrug resistant tuberculosis treatment.
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