Developing effective therapeutics for stroke, extending beyond brain injury to overcome the post stroke complications is the need of hour. Post-stroke recovery is a primary research goal, necessitating treatments targeting multiple aspects of stroke pathology to enhance patient outcomes. Co-administration of therapies presents a promising approach to address post-stroke complications. Here, we assessed the combined effect of Metformin (MET) and Coenzyme Q10 (CoQ10) in mitigating post-stroke injury in rats. Rats underwent bilateral common carotid artery occlusion followed by reperfusion. They were divided into groups: Sham, IR (ischemic reperfusion), MET-treated, CoQ10-treated, and co-administered (MET+CoQ10). All treatments were given intramuscularly for 1–3 days post-stroke. Brain infarct size was significantly reduced in all treatment groups as compared to IR. Neurological score, % alteration, transfer latency, and discrimination ratio are ameliorated in all treatment groups. Coadministration shows a significant reduction in LPO as compared to IR and MET-treated animals. Glutathione and BBB integrity improved in all treated groups. Histology shows less pyknosis and vacuolization in treated rats’ hippocampus. MET and CoQ10 treatment for 3 days post-stroke exhibited neuroprotective effects and improved cognitive function. Co-administration demonstrated enhanced antioxidant defense compared to individual treatments, suggesting potential synergy in mitigating post-stroke complications.
Key words: Post-stroke injury; Metformin; Co-enzyme Q10; Stroke; Oxidative stress; Behavioral activity
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