Aims: The study was performed to compare the analgesic activity of different fractions of the extracts of Ruta graveolens and Matricaria chamomilla.
Materials and Methods: The plant materials were extracted with 70% ethanol, petroleum ether, ethyl acetate and n-butanol. The ethyl acetate and n-butanol fractions of each plant were evaporated to dryness and analyzed by HPLC. The analgesic activity of these extracts was evaluated using writhing reflex test and compared with that produced by a standard drug (Diclofenac sodium).
Results: Flavonoids were found in all fractions of both plants (i.e ethyl acetate and n-butanol), while trace of alkaloids in were found in the ethyl acetate fraction of Ruta. The prepared extracts showed better analgesic activity than the standard drug; when compared with each other, Matricaria extracts showed better analgesic activity compared to Ruta extracts.
Conclusion: There is similar efficacy of chamomile and common rue as analgesic agents.
Key words: Ruta graveolens, Matricaria chamomilla, analgesic activity
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