Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



Evaluation of the impact of cigarette smoking on platelet parameters

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo.




Abstract

Background: Smoking has been established as a chief causative factor for cardiovascular diseases, inflammatory disorders, and oxidative stress stimulation. It is known that the total peripheral blood leukocyte count increases by cigarette smoking; however, its influence on platelet parameters is largely unknown. Early detection of thromboembolic diseases can be achieved by the potentially useful platelet indices. Enhanced activity is shown by platelets with increased volume when compared with platelets with smaller volume. Hence, mean platelet volume (MPV) can act as a indicator for platelet activity.

Aims and Objective: To study the impact of cigarette smoking on platelet parameters.

Materials and Methods: This crosssectional study included 50 healthy young male cigarette smokers and 50 healthy male nonsmokers in the age range of 18–50 years at SRM Medical College, Tamil Nadu, India, after approval by the institutional ethical committee. Subjects with acute illness and diabetes mellitus and those on antiplatelet drugs were excluded. History regarding current smoking status, number of cigarettes smoked per day, pack-years of smoking, and years since quitting was noted. Complete blood count including platelet indices such as platelet count, MPV, platelet distribution width (PDW), platelet large cell ratio (P-LCR), and plateletcrit (PCT) were determined. On the basis of their smoking characteristics, smokers were grouped as mild, moderate, and heavy.

Result: Compared with nonsmokers, smokers showed significantly high values of MPV, and PDW (P o 0.05). MPV, PDW, and P-LCR were found to be positively associated with intensity of smoking, pack-year, and duration of smoking.

Conclusion: The smokers showed higher MPV, PDW, and P-LCR, which might forecast possible high risk for developing thromboembolic disease in smokers.

Key words: Smokers, Platelet Count, Mean Platelet Volume






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.