Cordia macleodii has long served as a medicinal plant for its hepatoprotective and wound healing properties. People utilize this plant in treating various diseases due to the presence of relatively high levels of flavonoids, alkaloids, steroids, and terpenoids. This study aimed to investigate the in vitro antibacterial and antioxidant properties of Cordia macleodii methanol leaf extract. The antioxidant activity of the methanol extract of Cordia macleodii leaves was determined using the DPPH scavenging test, total phenol content (TPC), and total flavonoid content (TFC). The antibacterial activity was evaluated using the disc diffusion method. The extract exhibited significant dose-dependent antioxidant activity comparable to ascorbic acid. The total flavonoid content was 611.9 mg/g, and the total phenol content was 164.4 mg/g. The DPPH free radical scavenging assay indicated an ascorbic acid production of 523.21 μg/ml, while routine tests showed 18.35 μg/ml. Additionally, the leaf extracts demonstrated strong antibacterial activity against various bacteria, even exceeding the effectiveness of Ciprofloxacin. Further research is necessary to develop targeted therapies, potentially opening new avenues for harnessing the medicinal properties of Cordia macleodii. Clinical studies are also needed to investigate its potential as an alternative medicine.
Key words: Cordia macleodii, DPPH method, plant extract, alternative medicine, in vivo study
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