Background & Methods: Osteoporosis is a silent disease because bone loss occurs without symptoms. This disease is considered one of the most common health problems for women in menopause, and it results in a rapid loss of bone density. This study was conducted in DEXA (dual-energy X-ray absorptiometry) at Al-Sadr Teaching Hospital in Najaf Governorate / Iraq in the period (of February 2024– March 2024). In postmenopausal Iraqi women
Methodology: Blood samples were collected from (90) postmenopausal women, (35) who were diagnosed with Osteoporosis, (25) samples who were diagnosed with Osteopenia, and (30) samples as a control group. Patients were diagnosed as osteoporotic and controls as usual by measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DEXA). In addition, calcium, magnesium, sodium, albumin and uric acid are measured by spectrophotometry, while serum (leptin, interleukin (IL-1a-IL-6), vitamin D3, sclerostin and Dikkopf_1) are measured by enzyme-linked immunosorbent assay. (ELISA)
Data were collected by directly interviewing women using a special questionnaire that included Age, weight, height, and time of menopause. The study excluded premenopausal women and men, and the study also excluded those applying for osteoporosis treatment.
Results: The mean BMI of osteoporotic women is 21.10±3.65 kg/m2, revealing a significant (p-value 0.001) decrease compared to the mean BMI of the control group, which is 25.58±3.88 kg/m2, respectively.
Statistical significance (p
Key words: Leptin; sclerostin, interleukins, bone protein, Osteopenia; BMI, postmenopausal Osteoporosis, bone mineral density.
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