Abstract

Aim:
The present study is to evaluate the invitro antidiabetic activity of Mukia maderaspatana ethanolic extract and fractions by α-glucosidase and α -amylase inhibitory activity.
Methods:
Inorder to evaluate if the extraction procedure could influence the activity, we decided to extract with ethanol and fractions with chloroform and n-butanol of Mukia maderaspatana and test each of them with enzyme α-glucosidase and α -amylase inhibitory activity .
Results:
Mukia maderaspatana ethanolic extract and fractions showed dose dependent inhibition of α-glucosidase and α -amylase enzyme and exhibited lower inhibitory activity than acarbose.
Conclusion:
The study revealed the antidiabetic potential and could be helpful to develop medicinal preparations and nutraceuticals and function foods for diabetes.

Key words: Mukia maderaspatana, α-Glucosidase/ α –amylase inhibitor, Diabetes, Nilgiris