This study investigates the development and optimization of multilayer mucoadhesive tablets for controlled drug delivery, employing chitosan extracted from prawn (CP) and crab (CC) shells. Characterization of chitosan reveals variations in the degree of deacetylation (DD) and solubility, mucoadhesion, with CP showing higher DD and improved solubility compared to CC. Both CP and CC formulations demonstrate effective drug release retardation and substantial mucoadhesive strength. This study explores the incorporation of Eudragit S 100, and HPMC K 300, as novel backing layers beside ethyl cellulose, expanding the scope of buccal drug delivery system development. Optimization of formulation parameters, including chitosan and backing layer concentration, refined drug release kinetics. The multilayer design enables sustained drug release for a longer period, particularly notable at limited chitosan concentrations, by establishing a controlled pathway for drug diffusion.
Key words: Mucoadhesive Buccal Tablets; Controlled drug delivery; Chitosan; Eudragit S 100; HPMC K 300;
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