Background: Fast dissolving oral thin films (FDTFs) offer a promising delivery platform for drugs with poor aqueous solubility and bioavailability. Eugenol, a natural compound with diverse pharmacological properties, faces challenges in oral delivery due to its low aqueous solubility and high volatility.
Objective: This study aimed to develop a fast dissolving oral thin film formulation of eugenol to enhance its bioavailability and facilitate convenient administration.
Methods: The FDTFs were prepared using a solvent casting method with hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG) as film-forming agents. The formulations were optimized based on criteria such as film thickness, folding endurance, tensile strength, disintegration time, and drug release profile. Characterization studies to evaluate the physicochemical properties of the optimized formulation.
Results: The optimized eugenol-loaded FDTFs exhibited desirable mechanical properties, rapid disintegration, and enhanced drug release compared to conventional dosage forms.
Conclusion: The developed fast dissolving oral thin film of eugenol holds promise as a novel delivery system for enhancing the bioavailability of eugenol.
Key words: Fast dissolving oral thin films, Eugenol, Solvent Casting Method, Hydroxypropyl methylcellulose (HPMC), Plasticizer, Surfactant
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