Abstract

Background: Individuals with type 2 diabetes mellitus and pre-diabetes have an increased risk of coronary artery disease. Thyroid dysfunction may amplify existing cardiovascular disease risk in hyperglycemic subjects. Studying the association between thyroid profile abnormalities in the pre-diabetes population is of considerable clinical importance.

Aims and Objectives: The aims and objectives of the study are to study thyroid profile in pre-diabetes and control.

Materials and Methods: Group-I: Patients with pre-diabetes are considered cases. (patients with fasting plasma glucose [FPG] – 100–125 mg/dL and/or post-prandial blood glucose 140–199 mg/dL and/or hemoglobin A1c [HbA1c] – 5.7–6.4% as per “American Diabetes Association 2017”). Group-II: Patients with normal FPG, post-prandial blood glucose, and HbA1C are considered controls.

Results: Among pre-diabetes, 12% have hypothyroidism as compared to 5% among non-diabetic (P < 0.001).

Conclusion: There is a significant increase in the prevalence of hypothyroidism among the prediabetes population. Hence, they should be screened early for these parameters and early management may reduce future cardiovascular morbidity and mortality.

Key words: Pre-diabetes; Thyroid Profile; Significance