Background: Peripheral neuropathy is a broad term encompassing any condition that impacts the peripheral nerves. It encompasses a wide range of conditions, presenting with a variety of abnormalities that affect different aspects of both the voluntary (somatic) and involuntary nervous systems (autonomic nervous system). The manifestations of peripheral neuropathy can vary significantly based on the specific nerves affected. This disorder can induce numbness, tingling, or pins and needles sensations along with sharp and pulsating pain. Commonly employed medications for treating peripheral neuropathy encompass analgesics such as opioids and over-the-counter pain relievers, as well as anti-epileptic drugs such as topiramate, gabapentin, and pregabalin. For enhancing the management of peripheral neuropathy, it is imperative to gather data regarding the prevailing utilization trends of medications prescribed for neuropathic pain. Drug utilization studies constitute continuous activity for evidence based therapeutic practices; it implies rational therapy with focus on the prime parameters. This study aims to assess the drug utilization pattern for peripheral neuropathy under various prescriptions which provides the scope for various etiologies and severity requiring judicious choice of drug use.
Aims and Objectives: The objective of the study was to assess the pattern of medications dispensed to patients diagnosed with various types of peripheral neuropathy at a tertiary care center and to evaluate the drug regimen given for particular type of peripheral neuropathy.
Materials and Methods: It is a cross-sectional observational study conducted at a neurology outpatient department at a tertiary care center. Patients diagnosed with peripheral neuropathy due to various disease conditions were included in the study. Patients were selected through convenient sampling. Prescriptions were reviewed to evaluate the medication profile, comprehensiveness, and concordance with the diagnosed condition. Drug details were analyzed utilizing the descriptive statistics within Statistical Package for the Social Sciences software version 29.0.
Results: Our study included a cohort of 110 patients diagnosed with peripheral neuropathy due to various disease conditions. The mean age of the study participants were 43.4 years, 58 were males, and 52 were females. Out of 110 patients 58 (52.7%) patients were prescribed pregabalin + methylcobalamin, 38 (34.5%) patients received methylcobalamin alone, 8 (7.2%) patients received duloxetine, 5 (4.5%) patients received the combination of pregabalin and amitriptyline, and 1 patient with peripheral neuropathy due to hypothyroidism received levothyroxine.
Conclusion: In our study, the predominant medication utilized for peripheral neuropathy treatment is the combination of pregabalin and methylcobalamin, with methylcobalamin monotherapy being the subsequent choice.
Key words: Peripheral Neuropathy; Methylcobalamine; Pregabalin; Diabetes
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