Objective: The effective management of postoperative pain in bariatric surgery poses significant challenges for anesthesiologists and surgeons. The objective of this study was to assess the effects of opioid-free anesthesia (OFA) utilizing the modified mulimix technique on the levels of plasma interleukin-2 (IL-2) and interleukin-6 (IL-6). In addition, the study aimed to evaluate the duration of analgesia and the analgesic requirements during the first 24 hours postoperatively.
Methods: A total of 60 patients were randomly assigned to the OFA Group, which received opioid-free anesthesia, and the OCA Group, which received Opioid-Containing Anesthesia. The modified Mulimix technique was used in both groups. Serum samples were collected from all patients during skin incision and after the surgical procedure. Subsequently, these samples assessed interleukin-2 (IL-2) and interleukin-6 (IL-6) levels. Furthermore, the postoperative analgesic consumptions were documented.
Results: Regarding serum interleukins IL-2 and IL-6 levels in the two study groups, there was a statistically significant difference after the conclusion of surgery, and the skin incision was made. Regarding the initial rescue analgesia postoperatively assessment, the OCA group demonstrated a substantially greater overall consumption of analgesics within a 24-hour. The study revealed a significant difference in VAS values between the OCA Group and the OFA Group at 2 hours, 4 hours, and 6 hours postoperatively.
Conclusion: The modified Mulimix technique has effectively reduced postoperative inflammatory mediators, and decreased postoperative pain as well as reduced postoperative analgesia consumption
Keywords: bariatric, interleukin, Mulimix, opioid, pain, immunological response.
Key words: bariatric, interleukin, Mulimix, opioid, pain, immunological response
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