Abstract

Background: Hysterectomy is the most common operation with a postoperative pain score for abdominal hysterectomy is 8. Administering preemptive analgesia can reduce postoperative pain. We determined the differences in opioid requirements and serum magnesium levels in post-abdominal hysterectomy patients who received magnesium sulfate at a dose of 50 mg/kg or 30 mg/kg.
Methodology: This is a double-blind, randomized controlled clinical trial with 40 women undergoing abdominal hysterectomy as participants. The participants were randomly divided into two groups; group I received magnesium sulfate at a dose of 50 mg/kg and group II received a dose of 30 mg/kg.
Results: Magnesium sulfate at a dose of 50 mg/kg had 162.5 µg lower postoperative opioid requirements compared to the group at a dose of 30 mg/kg. The analysis also showed a significant difference in blood magnesium levels between the two groups, with the 50 mg/kg dose group (2.36 ± 0.29 mEq/L) higher than the 30 mg/kg dose group (2.13 ± 0.23 mEq/L).
Conclusion: Administering magnesium sulfate at a dose of 50 mg/kg to abdominal hysterectomy patients can reduce the need for opioids and increase magnesium levels in the blood significantly compared to a dose of 30 mg/kg.

Key words: abdominal hysterectomy; magnesium sulfate; opioid; preemptive analgesia