Abstract

Cassine albens (R.) Kosterm belongs to the family celastraceae which is the rich
source of triterpenes and alkaloids. In present study hydroalcoholic extract of stem bark of Cassine
albens was investigated for antidepressant and anxiolytic activity in rodents. The dose dependant
study was performed at the doses of 100, 200, 400 and 800 mg/kg, p.o. Cassine albens showed
significant antidepressant activity in forced swim and tail suspension test. We observed significant
anxiolytic effect at the dose of 400 and 800 mg/kg, p.o. in elevated plus maze and marble burying
test in rodents. The present study substantiates folkloric use of Cassine albens in the treatment
of psychosomatic disorders.

Key words: Cassine albens, Neurotransmitter, Antianxiety, Antidepressant.