This experiment evaluated the effect of the aqueous extract of Urtica dioica leaves
and the ethanolic extract of Picrorhiza scrophulariiflora rhizome on the glycemic and lipidemic
status in type 1 diabetic model rats. Adult Long Evans male rats, bred at BIRDEM animal house,
Dhaka, Bangladesh were used in this study. Type 1 diabetic model rats were produced with a single
intraperitoneal injection of Streptozotocin using standardized method used in BIRDEM. Serum
glucose was estimated by the glucose-oxidase (GOD-PAP) method, serum lipid profiles (cholesterol,
triglycerides, HDL) were measured by enzymatic colorimetric (cholesterol oxidase / peroxidase)
method. Significant blood glucose lowering effect of U. dioica (p
Key words: Type 1 diabetes, Streptozotocin, Urtica dioica, Picrorhiza scrophulariiflora,
Animal model, Glycemic status, Lipidemic status.
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