Homeopathy is a complete medical system based on principles of similars anddilutions that have an effect on the potentization of the drug activity. However, for a number of people Homeopathy is a controversial area of Complementary and Alternative Medicine (CAM)that provided a scientific rationale for testing to reevaluate its principle and theory by proving its effects on healthy experimental animals. The hepatoprotective preparation of Chelidonium majus in 30 C and 200 C potencies were subjected to antioxidant assay. Their effects on behavioral pattern and serum biochemical variables including protein content, glutamic oxaloacetic transaminase (SGOT),glutamic pyruvic transaminase (SGPT), total and direct bilirubin in healthy Wistar rats were evaluated in a 28 days single-dose study period. The results revealed moderate antioxidant activity and hepatotoxic effects indicated by significant increase in SGOT and SGPT levels in the first14 days were exhibited predominantly by 200 C than 30 C is in view of the similie principle.
Key words: Law of similars, Law of dilutions, Chelidonium majus, Potencies, Biochemical Variables, Homeopathy.
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