The current study was conducted to evaluate the cardioprotective potentials of eugenol against hypertension induced by doxorubicin in rats. Rats were exposed to Doxorubicin HCl (2mg/kg body weight) intraperitoneally to induce cardiotoxicity and treated with eugenol (5 mg/kg) orally for 5 weeks. At the end of the study, the blood pressure was assessed in the tested animals and the levels of serum lipid profile and oxidative stress markers were assessed. Also, the heart was dissected and the oxidative stress and apoptotic markers in heart homogenate were assessed. There was high statistically significant difference between all the tested groups regarding the systolic blood pressure and mean arterial pressure. The Serum oxidative stress markers and lipid profile markers showed a statistically significant increase in the positive control group compared to other groups. The heart homogenate level of all the tested parameters showed a statistically significant increase in the positive group compared to other groups except for the MDA levels that was comparable between the positive group and protection group. Eugenol's antioxidant and lipid-lowering properties protect against hypertension. Eugenol's antioxidant and anti-apoptotic effects protect the heart from hypertension's long-term effects at the tissue level.
Key words: Hypertension, eugenol, Doxorubicin, Apoptosis, Oxidative stress, Rats.
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