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Original Research

AAM. 2012; 1(3): 71-76


Genetic variation at the CXC chemokine IP-10(CXCL10) in parallel with its increased serum level in south-eastern Iranian multiple sclerosis patients

Hossein Karkamandi, Seyed-Mostafa Hosseini-zijoud, Javad Hosseini.




Abstract

Aim: Immune system-related factors are important in pathogenesis of multiple sclerosis IP-10 as CXC chemokines are involved in the immune responses. Hence, this study was to investigate the association between multiple sclerosis and serum level of IP-10.
Methods: In this experimental study, blood samples were collected from 100 multiple sclerosis patients and 100 healthy controls on EDTA pre-coated tubes. Demographic data were also collected by a questionnaire which was designed specifically for this study.
Results: Our results showed that serum level of IP-10 was significantly higher in the patients than healthy controls.
We are also showed that relapsing remitting multiple sclerosis )RRMS( patients with a good economical status had elevated IP-10(CXCL10) in compare to median group (P

Key words: Multiple sclerosis, IP-10(CXCL10), Polymorphism, chemokine.






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