Evaluation of interleukin-33 and osteopontin levels in well and poorly regulated diabetes mellitus type 2
Ozlem Ozdemir, Tevfik Noyan, Abdullah Uner, Cagri Akalin.
Abstract
IL-33 is one of the novel IL-1 family members which are secreted in many tissues. Osteopontin (OPN) is a highly phosphorylated and glycosylated sialoprotein synthesized primarily in bone tissue, which the major role is to participate in biomineralization. Both IL-33 and OPN are mentioned associated with inflammatory disorders. Diabetes Mellitus Type 2 (T2DM) is a metabolic disorder in glucose homeostasis, which its pathophysiology involves a low-grade chronic inflammation. The aim of this study is to evaluate the IL-33 and OPN levels in well and poorly regulated T2DM patients. Three group were determined as; T2DM with HbA1c level below 8% as Group HbA1c
Key words: IL-33, osteopontin, hbA1c, diabetes mellitus type 2
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