Abstract

Background: Type 2 diabetes mellitus (T2DM) is associated with a cluster of interrelated plasma lipid and lipoprotein abnormalities including reduced HDL cholesterol.

Objective: To compare the lipid profile and new atherogenic indices among the coronary artery disease (CAD)-negative and -positive diabetic dyslipidemia subjects and determine the use of atherogenic indices in the early prediction of CAD in diabetic subjects.

Materials and Methods: A total number of 194 subjects participated in our study, of which 65 people with diabetic dyslipidemia were considered cases and 129 nondiabetic people with normal lipid profile were considered control subjects based upon their fasting blood glucose (FBG) and lipid profiles. Furthermore, among the 65 cases, 38 subjects were identified as CAD negative and rest of the 27 subjects were CAD-positive subjects.

Result: Lipid profiles of both CAD-negative and -positive diabetic subjects showed significantly different values than the control subjects except for high-density lipoprotein cholesterol (HDL-c) value (41.89 ± 1.49; p > 0.05) of CAD-negative subjects. The comparison between the CAD-negative and -positive diabetic dyslipidemia subjects observed significantly higher values of triglycerides (339.59 ± 52.24; p < 0.001) and very low-density lipoprotein cholesterol (VLDL-c) (67.91 ± 10.44; p < 0.001) and lower values of HDL-c (35.59 ± 1.40; p < 0.001) in CAD-positive subjects. When compared with control subjects, both CAD-negative and -positive subjects showed higher values of atherogenic indices that were significantly (p < 0.01 and p < 0.001, respectively) different.

Conclusion: Our results indicate that atherogenic indices may be useful for identifying individuals at higher risk of cardiovascular disease in the clinical practices, especially, not markedly deranged or in centers with insufficient resources.

Key words: Diabetic dyslipidemia, coronary artery disease, atherogenic indices