Acrylamide first received global attention in April 2002 when Swedish researchers reported finding the chemical in fried and oven-baked foods, especially in potato chips and French fries. The present study illustrates the comparative hazardous effects of acrylamide and fried potatoes chips food supplementation during prenatal life (14, 16 & 17 days), as well as at parturition. The present findings reported closely similar histological abnormalities in the mentioned maternal tissues as a result of acrylamide intoxication or during food supplementation of fried potatoes chips. The epiphyseal cartilage of experimental mothers exhibited highest drastic alterations of cell structures. Both acrylamide-treatment and fried potatoes chips supplementation increased the rate of aborted mother during the progress of gestation, increased neonatal mortality and reduced the total numbers of newly born comparing with the control. The prenatal foetuses (14, 16 & 17 day-age), as well as delivered newborn maternally-fed on diet containing fried potato chips or maternally treated with acrylamide exhibited a marked reduction of their body weight, size & crown-rump length comparing with the control group. Different patterns of congenital malformations were observed at higher rates in those of mothers fed on fried potato chips than those maternally treated with acrylamide. The ossification of axial and appendicular bones were markedly retarded during prenatal growth till parturition and assessed by reduction of length measurement of ossified bones of both mandibular and appendicular regions. Assaying the incidence of missing ossified bones in newly born of the different experimental groups revealed that the retarded ossified regions restricted mainly in tympanic region, sternbrae, clavicle, ischium, distal phalanges of fore-& hind limbs as well as caudal vertebrae. Highest incidence of missing ossification centres was detected in newly born maternally fed on diet containing fried potato chips comparing with those maternally treated with acrylamide. Histogenesis of tympanic region, ribs and humerus and radio-ulna revealed massive retarding skeletal cell elements including chondroblast and osteoblast building cells as a result of acrylamide-treatment or fried potatoes chips supplementation.
Key words: Acrylamide, fried potatoes, pregnant mice, offspring
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