The ameliorative effect of Antox and Singular drugs, separately or in combination, against paraquat, herbicide-induced lung toxicity were studied in albino rat (120 ± 10 g BW). Paraquat was injected as a single dose of 1/20 LD50 (2.5 mg /kg BW, i.p.). Whereas antox (0.27 ml/ 100 g BW, orally), singular (0.23 ml/100 g BW, orally) and Antox + Singular were introduced for the rats (once a day for 4 weeks) 48 hours - after paraquat injection. Blood catalase, serum superoxide dismutase and c- reactive protein, as well as interleukin- 6 recorded highly significant elevation due to paraquat lung intoxication. During intervals (1, 2, and 4 weeks) of drugs treatment, the therapeutic effect of Antox or Singular, separately, was limited compared to that of their combination. However, the longer the time after (Antox + Singular) treatment the more is the amelioration for the studied biomarkers. The mechanisms of paraquat induced lung intoxication and the therapeutic effect of Antox and Singular drugs were discussed.
Key words: Paraquat, Rats, Lung, Toxicity, Antox, Singular
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