Abstract

The present work was performed on 50 male albino rats to study the ameliorative effects of camel’s urine and milk, honey and Nigella sativa mixture and ginger against the toxicity of haloperidol on the duodenal histological of male rats. Rats were divided into five groups (10 rats each). The first group was taken as Control. The second group was intramuscularly injected with 0.1 ml/rat of haloperidol (equivalent to the human therapeutic dose) for 16 weeks, while the other groups; 3, 4, and 5 were treated daily with 0.1 ml of haloperidol and then they were orally given 1 ml of the Camel’s urine and milk, honey and Nigella sativa mixture and ginger, respectively for 16 weeks. The main observed changes after treatment showed haloperidol induced many histopathological alterations on the duodenal tissues, whereas, groups 3-5 revealed significant reduction in the changes induced by haloperidol. Moreover, the Camel’s urine with milk displayed more efficiency in decreasing the toxic effects produced by haloperidol.

Key words: Camel’s urine and milk, Haloperidol, Nigella sativa, honey, ginger, duodenum.