The effects of long term feeding (12 weeks) of deeply fried oils on the histology and ultrastructure of adult male albino mice liver are studied. The animals are divided into three groups (15 mice each). The first group is fed on a standard diet and served as a control. The second group is fed on a diet containing 25% of heated fried oil. The third group is fed on a diet contains a mixture of olive and fried oil in equal ratio. Histopathological examination showed many alterations in the liver tissue. The observed hepatic lesions are mild to severe distortion of the normal architecture of the liver, prominence widening of the central veins, fatty degeneration, peri-vascular and focal necrosis associated with granulomas. At the ultrastructure level, vesicuolation of rough endoplasmic reticulum, electron-dense mitochondria and convolution of the nuclear envelope with dense peripheral clumping of heterochromatin particles as well abundant distribution of cytoplasmic lipid globules with almost distorstion of cytoplasmic organelles were observed. Olive oil is found to induce partial recovery of these hepatic abnormalities.
Key words: Fried oil, Histopathology, Liver, mice
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