Aim: We tested the hypothesis that administrations of methanolic extracts of Musa sapientum sucker (MEMS) with exercises attenuated hyperglycaemia in alloxan-diabetic rats.
Methods: Forty adult male rats were divided into equal eight groups. Normoglycaemic Group A was Control. Alloxan (180 mg/kg, i.p.) was administered to rats in Groups B H to induce diabetes. Group B (diabetic control) received physiological saline. Groups C - H received MEMS (5 mg/kg), MEMS (10 mg/kg), MEMS (5 mg/kg) + exercises, MEMS (10 mg/kg) + exercises, Glibenclamide (5mg/kg) and Exercises only respectively. Changes in body weight, blood glucose levels (BGL) and pancreatic histology were evaluated during or at the end of experiment. Bodyweights and BGL of rats were expressed as mean ± standard deviation and analyzed using the statistical software program SPSS 15. Statistical comparisons were done using the Students t-test for unpaired samples. Differences between groups were determined as significant at P values ≤0.05.
Results: Significantly (p
Key words: Musa sapientum, alloxan, hyperglycaemia, pancreatic islet cells, rats
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