Objective: To assess cardiovascular changes in the use of epinephrine in septoplasty as well as to achieve the optimal dilution of the epinephrine to minimize these changes.
Methodology: In a randomized clinical trial, 100 patients who were about to undergo septoplasty in Imam Reza hospital, Tabriz, Iran, were randomly assigned to receive epinephrine with the dilution of 1:200,000 (group A) or lidocaine containing epinephrine with the dilution of 1:80,000 (group B). The changes in blood pressure, heart rate, and bleeding were compared between the two groups.
Results: There was no significant difference between the two groups in terms of gender, age, duration of operation, history of surgery on nasal septum, complications in previous surgeries, and the drugs used for anesthesia. However, the increase in blood pressure, and the bleeding in group A was significantly more than that in group B (14% vs. 2%). There was no significant difference between the two groups in terms of fluctuations in heart rate.
Conclusion: The use of lidocaine 2% with epinephrine 1:80,000 is preferable than the epinephrine 1:200,000 in terms of amount of bleeding and changes in blood pressure in septoplasty.
Key words: Septoplasty, epinephrine, lidocaine, blood pressure, heart rate, bleeding
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