ANTIFUNGAL ACTIVITY OF CARICA PAPAYA SEED EXTRACT AGAINST ASPERGILLUS FLAVUS AS SERIOUS MYCOTOXINS PRODUCING ORGANISM AND CAUSAL ORGANISM FOR ASPERGILLOSIS
Eman Hassan Fathy Abd El-Zaher.
Abstract
Aqueous Carica papaya seed extract was investigated for its antifungal activity against Aspergillus flavus using cut plug method. C. papaya seed extract has inhibitory activity against A. flavus with inhibition zones ranging between 11 to 16 mm. A. flavus cells surviving ratio was decreased with increasing the C. papaya seed extract concentrations from 25 to 200 mg/ml. Treating the organism with C. papaya seed extract led to an external changes, irregular cell shape and disintegration of fungus cell wall under transmission electron microscope. On other hand, studying the effect of the aqueous C. papaya seed extract on mice lung has showed safe effect which might explore in lung disease treatment. Furthermore C. papaya had antioxidant characters. Analysis by GC-MS showed at least 15 components, esters were the most abundant group of compounds.
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