Potentials of phytotherapy on microRNAs in chronic kidney diseases
Akhi Moni; Md Jamal Uddin.
Abstract
Chronic kidney diseases (CKD) describe the loss of renal function and/or abnormal structure. CKD is linked with inflammation, oxidative stress, fibrosis, autophagy dysfunction, and mitochondrial dysfunction [1]. Currently, treatment focuses on the management of symptoms, which emphasis the need of novel therapeutic options [2]. On the other hand, dysregulation of specific microRNA (miRNA) is associated with abnormal kidney function, rendering them important targets for treating CKD. The roots, leaves, stems and various bioactive compounds of herbal plants appear as a potential candidate for CKD therapy [3]. Thus, the current study emphasizes the phytotherapy that alters the miRNAs that are associated with CKD, focused their mechanisms and therapeutic avenues.
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