The neurobiology of switching phenomenon is unclear and no common definition exists to describe it. Several factors such as neurobiological problems, sleep deprivation, and drugs appear to be associated with mood switches. Frequently accused drugs are exogenous corticosteroids, dopaminergic agonists, and antidepressants. Lamotrigine is a mood stabilizer that is used in the treatment of treatment-resistant unipolar depression and bipolar depression. In many clinical trials, manic or hypomanic switch risk of lamotrigine has been reported to be not more than placebo. Here, we report a female patient with recurrent depressive disorder who developed manic switch after adding lamotrigine to her treatment regimen.
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