Malaria continued to be world health problem that causes loss of lives annually in most especially pregnant woman and children. However, quinine proved to be effective in the case of treating malaria due to its rapid schizonticidal action against intra-erythrocytic malaria parasites. Furthermore, nanoparticles of drugs was found to be suitable drug carrier system that have the potential to reduced drug toxicity and increase its effectiveness. The study formulated and characterized the quinine-solid lipid nanoparticles (Q-SLNs) and to see its potential as drug-delivery system. The quinine Solid lipid nanoparticles were prepared using modified solvent emulsifica¬tion evaporation method based on a water-in-oil-in-water (w/o/w) double emulsion, while drug loading (DL), encapsulation efficiency (EE), thermogravimetric analysis (TGA), derivative thermal analysis (DTA) and surface morphology of the Q-SLNs as well as the free drug were analysed using standard methods. The result revealed that drug loading and encapsulation efficiency of the Q-SLNs were found to be 25% and 75% respectively. Similarly, the exact degradation point of nano formulated quinine was found to be 400°C, whereas it is 330°C for free quinine with morphological spherical shape. The present study, therefore, signified that the Q-SLNs may have higher level of distribution with enhanced efficiency of cell internalisation than the free quinine which may also reduce toxicity and level of circulation to the target site.
Key words: Quinine-Solid Lipid Nanoparticles formulation and characterisations
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