ANTI-DIABETIC EFFECT OF Parkia biglobosa LEAF METHANOL EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS
Jude Nwaogu, Yakubu Musa Yanah.
Abstract
Diabetes mellitus is characterized by chronic hyperglycaemia with disturbances of carbohydrates, fat, and protein metabolism resulting from the defect of insulin secretion or insulin action. Parkia biglobosa is traditionally used in Nigeria to treat a range of ailments and diseases including diarrhoea, pneumonia, ulcers, burns, coughs, jaundice and diabetes. In this study, the anti-hyperglycemic effect of methanol leaf extract of P. biglobosa was investigated against Alloxan induced diabetes in rats. A total of twenty-five (25) rats were randomly allocated to 5 groups of 5 rats each. Group 1 served as the negative control, group 2 served as diabetic control, Group 3 received standard drug and serve as positive control (glibenclimide 2.5mg/kg) while Groups 4-5 were treated with methanol leaf extract of P. biglobosa (100mg and 300mg) respectively. Results obtained reveal that no significant decrease (p
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