Background: Obesity is a classical metabolic disease that induces inflammation evidenced by various inflammatory markers in the circulation. Chronic inflammation is one of the risk factors to cause insulin resistance and leads to diabetes mellitus. Hence, the current study aimed to find the association between inflammatory markers and insulin resistance in young medical students.
Aim and Objective: The aim and objective are to study the association between inflammatory markers and insulin resistance in young medical students.
Materials and methods: A cross-sectional study was undertaken in 60 young medical students of both genders of the host institute divided into two groups based on their body mass index (BMI). All the participants were examined by a clinician for their history of illness and parenteral illness. Later their fasting blood samples were collected and stored at a frozen temperature to measure fasting blood sugar (FBS), insulin, high-sensitivity C-reactive protein (Hs-CRP), and insulin resistance along with basic demographic data.
Results: The mean age of participants in group 1 (cases) was 21.86 ± 3.87 years and in group 2 (controls) 20.95 ± 4.22 years. The BMI of the case group 27.34 ± 2.39 kg/m2 is significantly higher than the control 21.69 ± 2.21 kg/m2 (P < 0.001). All glycemic and inflammatory markers are significantly higher in cases than controls showed statistically significant, FBS, Hs-CRP, insulin, and insulin resistance (P < 0.001). Although there was a similar trend between Hs-CRP and insulin resistance, the correlation has shown a weak association.
Conclusion: The current study reveals that the glycemic variables and inflammatory markers are significantly higher in the obese group than in the control group. The association of Hs-CRP with insulin resistance has shown a weak association, however, it was shown a better trend than controls, and further studies are warranted to provide new insights into obesity.
Key words: Obesity; Insulin Resistance; Hs-CRP; Inflammatory Markers
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