Background: Knee diseases may be related to inflammatory parameters such as vascular endothelial growth factor (VEGF-A) and interlukine-1 receptor antagonists (IL-1Ra). These biomarkers might provide diagnostic, prognostic, or burden information for knee disease.
Materials and methods: During the period from November 2022 to May 2023, a total of 76 Iraqi participants suffered from ACL injuries, meniscal tears, and cartilage damage. They were invited from the Al-Furat Al-Awsat Privat Hospital in the Al-Qadisiyah governorate, Iraq. Three groups of patients were created according to the duration of the disease: less than six months for Group I, six-twelve months for Group II, and more than one year for Group III. The enzyme-linked immunosorbent assay (ELISA) technique was used to detect inflammatory parameters (VEGF-A and IL-1Ra). Data were summarized, and Microsoft Office Excel 2013 and GraphPad Prism 9.2.0 were used to present the statistical analysis.
Results: Patients in Group I showed an elevated level of VEGF-A (372.2 ± 68.95 pg/mL) as compared to both Group II (273.5 ± 53.47 pg/mL) and Group III (232.2 ± 28.22 pg/mL) significantly (P< 0.0001). While the concentration of IL-1Ra declined in patients with Group III (162.1 ± 7.036 pg/mL), as compared with both Group II (173.1 ± 9.351 pg/mL) and Group I( 200 ± 34.53 pg/mL) with significant differences (P< 0.0001).
Key words: vascular endothelial growth factor, interlukine-1 receptor antagonists, synovial fluid, anterior cruciate ligament
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