Abstract

Developing a new agent in the anti-inflammatory and analgesic field, plants secondary metabolites can be a good source for the Non-Steroidal Anti-inflammatory Drugs (NSAID) drug development. For this purpose we subjected the active compounds of Mimosa pudica Linn. to reveals its potentiality by molecular docking analysis to find out its potent compound against COX which is done by GOLD docking analysis. Docking studies by GOLD shows that vitexin of Mimosa pudica has the highest fitness score against the COX-1 which is 60.43 and 63.49 for COX-2 enzyme. Vitexin of Mimosa pudica detected with significant fitness score and hydrogen bonding against COX-1 and COX-2 which may be a potent analgesic compound.

Key words: Mimosa pudica, Analgesic, Anti-inflammatory, COX, Vitexin, Mimosine