Micronucleus assessment as a biomarker and susceptibility to DNA damage in workers occupationally exposed to pesticides
Mohammed RafiqKhan, Godan Tharangad Krishnan, Ranjini Keezhekalam, Srinivasapuram Natarajan Suresh, Umadevi Pongiya and Yalaga Rama Rao.
Abstract
Occupational exposures to hazardous chemicals are common in industries using solvent based materials as well as in indoor environments where people are exposed to volatile organic compounds from various sources. The health of the workers has several determinants, including risk factors at the workplace leading to cancer. The aim of the present investigation was to assess the potential cytogenetic damage associated with occupational exposure among pesticide workers by using micronuclei and other nuclear abnormalities as a biomarker. The micronucleus assay on exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. To determine the genotoxic effects of pesticide workers, Micronucleus assay was carried out in exfoliated buccal cells of 50 pesticide workers and 50 controls. For each individual, 2,000 exfoliated buccal cells were analyzed. Micronucleus and other nuclear abnormalities frequencies in exposed were significantly higher than those in control groups (P
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