Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital
Background and Aims:
The LDL-C levels guide the cardiovascular risk assessment under the National Cholesterol Education Program Adult Treatment Panel (NCEP) as well as used for the management of dyslipidemia. Traditionally, LDL-C level is calculated using the Friedewald formula i.e., cLDL, however, recently many of the laboratories have shifted to newer methods of direct LDL-C estimation, i.e., dLDL. With this transition, there is increased demand to compare and establish updated LDL-C level cutoffs for the risk assessments of cardiovascular events.
Methods:
A retrospective observational study, comprising 216 study participants, was conducted in the Department of Biochemistry, Lady Hardinge Medical College, and associated hospitals, in New Delhi for 12 months. Data was collected from 216 adult patients (> 18 years) whose routine fasting lipid profile was done and documented in our clinical biochemistry lab. LDL-C levels done by direct method and calculated methods were compared using the Intraclass correlation coefficient (ICC). Appropriate statistical tests were used with a p-value
Key words: Direct homogeneous method, Friedewald equation, Lipid profile, LDL, National Cholesterol Education Program Adult Treatment Panel
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