Ketamine has emerged as an effective option for treatment-resistant depression (TRD), with a quick and long-lasting antidepressant effect, as well as anti-suicidal benefits. This bibliometric analysis uses a quantitative approach to determine the trend in publication and research themes related to ketamine and depression research. The literature search was conducted using a specific search query from the Scopus database. The downloaded data were analyzed using Publish or Perish and VOSviewer tools to perform citation and keyword analyses, respectively. A total of 994 articles were analyzed. Studies on ketamine and depression have shown an increasing trend annually since 2012. While the journal of affective disorders published more ketamine and depression-related articles, higher impact studies published in the biology of psychiatry garnered the most citations. Ketamine and depression-related terms topped the keyword co-occurrence analysis. All keywords were grouped into four clusters, cognitive effects of ketamine, mechanisms underlying antidepressant effects of ketamine, its safety and tolerability, and its anti-suicidal effects in TRD. The identified research themes from this review serve as a guide for researchers, practitioners, policymakers, and funding agencies to understand the research landscape and identify areas where more research is needed.
The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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