Ketamine has emerged as an effective option for treatment-resistant depression (TRD), with a quick and long-lasting antidepressant effect, as well as anti-suicidal benefits. This bibliometric analysis uses a quantitative approach to determine the trend in publication and research themes related to ketamine and depression research. The literature search was conducted using a specific search query from the Scopus database. The downloaded data were analyzed using Publish or Perish and VOSviewer tools to perform citation and keyword analyses, respectively. A total of 994 articles were analyzed. Studies on ketamine and depression have shown an increasing trend annually since 2012. While the journal of affective disorders published more ketamine and depression-related articles, higher impact studies published in the biology of psychiatry garnered the most citations. Ketamine and depression-related terms topped the keyword co-occurrence analysis. All keywords were grouped into four clusters, cognitive effects of ketamine, mechanisms underlying antidepressant effects of ketamine, its safety and tolerability, and its anti-suicidal effects in TRD. The identified research themes from this review serve as a guide for researchers, practitioners, policymakers, and funding agencies to understand the research landscape and identify areas where more research is needed.
Key words: ketamine; depression, bibliometric analysis, Harzing’s Publish or Perish, VOSviewer.
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