Background: Terminalia bellirica has been extensively investigated and used since time immemorial as part of Ayurvedic practice entirely because of its curable properties. Their antioxidant, hepatoprotective, antibacterial, and immunemodulatory activities are mostly attributed to the presence of glucoside, gallic acid, and its esters, chebulinic acid, etc.
Aims and Objectives: The aim of the study is to analyze the effects of sub-acute administration of T. bellirica fruit pulp aqueous extract (TBFPAE) in ameliorating pain in mouse models of the Swiss albino strain.
Materials and Methods: Young mice of Swiss albino strain typically 3 months’ of age; Male gender and weighing approximately 20–30 g were used for the purpose of the study. The mice were investigated by grouping them into five sets of six each randomly as control, standard, and trial groups. Group I was allotted as vehicle and given 1% gum acacia (10 mL/kg) as control; Group II was given pentazocine (5 mg/kg) as standard for central anti-nociceptive activity, while the IIIrd, IVth, and Vth groups received the investigative product TBFPAE per oral in doses of 9, 18 and 36 mg/kg, respectively. Eddy’s hot plate technique was employed for assessing central anodyne activity.
Results: All the test groups of TBFPAE were found to have an analgesic effect but doses 18 mg/kg and 36 mg/kg demonstrated greater effects, especially at 30 and 60 min. Maximum analgesic effect with TBFPAE was seen with 36 mg/kg dose at 60 min.
Conclusion: Therefore, T. bellirica has some analgesic potential. However, further studies are required to confirm its dose and usage.
Key words: Terminalia bellirica; Bibhitaki; Bahera; Aqueous extract; Anodynia; Swiss albino mice; Analgesia
|
