Calcineurin Level and Activity in Breast Cancer: Relation to Apoptosis
Manal Basyouni Ahmed, Maha Ismail, Muneera Al-Sheeha, Abeer Khamis.
Abstract
Background: Calcineurin (CN) is a Ca2+/calmodulin- dependent phosphatase and has been implicated in both transcription-dependent and transcription-independent apoptosis. Objectives: We aim to interpret the correlation between calcineurin and apoptosis in relation to pathogenesis of breast cancer. Methods: Both calcineurin level and activity as well as caspas-3 activity were evaluated in tissue homogenate of 50 breast cancer patients, 20 patients with fibroadenoma and 15 healthy women. Results: Calcineurin activity was significantly increased in malignant breast tissues compared with fibroadenoma and normal breast tissue (p=0.00) without significant changes in its level (p>0.05). While caspase-3 showed a significant higher activity in malignant group compared to other groups (p
Key words: Breast cancer, Calcineurin (CN) and Caspase-3.
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